Molecular Docking Studies of Antimalarial Drugs for Malaria

Molecular dynamics simulation and docking studies on the binding properties of several anticancer drugs to human serum albumin

Disposition and transportation of anticancer drugs by human serum albumin (HSA) affects their bioavailability, distribution and elimination. In this study, the interaction of a set of anticancer drugs with HSA was investigated by molecular dynamics and molecular docking simulations. The drugs' activities were analyzed according to their docking scores, binding sites and structural descriptors. ...

Studies on the Action of Synthetic Antimalarial Drugs on Indian Strains of Malaria

Cilional was introduced by Schulemann of Messrs. Bayer-Meister-Lucius, Germany, a few years ago. It belongs to the plasmochin series of preparations and has the composition di-alkylamino-alkyl-amino-oxy-quinoline. Its action on the gametocyte of Plasmodium falciparum was claimed to be as potent as that of plasmochin, in doses far less than, any that produced toxic symptoms. A total dose of 0.18...

Therapeutic responses to different antimalarial drugs in vivax malaria.

The therapeutic responses to the eight most widely used antimalarial drugs were assessed in 207 adult patients with Plasmodium vivax malaria. This parasite does not cause marked sequestration, so parasite clearance can be used as a direct measure of antimalarial activity. The activities of these drugs in descending order were artesunate, artemether, chloroquine, mefloquine, quinine, halofantrin...

Molecular docking studies on xanthohumol derivatives as novel ‎anticancer agents ‎

A set of Xanthohumol derivatives were selected and molecular docking studies of these ‎compounds on thioredoxin reductase were conducted. Based on new structural patterns using in ‎silico-screening study, new potent lead compounds were designed. The results due to validated ‎docking protocols lead to find that Thr58, Gly57, Gly21, Asp334, Glu163, Ala130, IIe332, ‎Val44 and Gly132 are the main a...

Studies on the Action of Antimalarial Remedies on Monkey Malaria